ChloroquineV1, Main, Exploration, bibRecord, 000237

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

Identifieur interne : 000237 ( Main/Exploration ); précédent : 000236; suivant : 000238

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

Auteurs : Hyo In Kim ; Se Hyang Hong ; Jin Mo Ku ; Min Jeong Kim ; Sung Wan Ju ; Seok Won Chang ; Chunhoo Cheon ; Seong-Gyu Ko

Source :

Nutrients [ 2072-6643 ] ; 2020.

RBID : PMC:7019269

Abstract

Gliomas are the most observed primary brain tumor, of which glioblastoma multiform (GBM) shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic method, but because of side effects, search for alternative therapies is required. Gardenia jasminoides (GJ) is flavonoid abundant with beneficial effects on inflammation, metabolic diseases, and cancers. In this study, we investigated the synergistic combination of GJ and cisplatin (CDDP) in U87MG and U373MG GBM cells. GJ and CDDP both showed cytotoxicity in U87MG cells, however GJ did not affect viability of normal astrocytes while CDDP displayed high toxicity. Cytotoxic effect of GJ and CDDP was related in apoptosis when confirmed by Western blot assays on cleaved caspase-3, caspase-9, and PARP. Moreover, GJ and CDDP showed synergistic combination in cell death of GBM cells, which was further confirmed by Western blot assays of apoptosis factors and also flow cytometry of Annexin V. Analysis on autophagy factors showed that GJ/CDDP combination induced autophagy, and through inhibition of autophagy, we could confirm autophagy is crucial to cytotoxicity of GJ/CDDP in GBM cell lines. The autophagy-mediated apoptosis of GJ/CDDP was dependent on the AKT/mTOR pathway. Overall, our results suggest GJ/CDDP combination as an effective yet safe therapeutic approach to GBMs.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019269

DOI: 10.3390/nu12010196
PubMed: 31936835
PubMed Central: 7019269

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Gardenia jasminoides</italic>
 Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes</title>
<author><name sortKey="Kim, Hyo In" sort="Kim, Hyo In" uniqKey="Kim H" first="Hyo In" last="Kim">Hyo In Kim</name>
<affiliation><nlm:aff id="af1-nutrients-12-00196">Department of Science in Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>hi9265@nate.com</email>
 (H.I.K.);<email>jung8328@hanmail.net</email>
 (M.J.K.);<email>seonca@naver.com</email>
 (S.W.J.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hong, Se Hyang" sort="Hong, Se Hyang" uniqKey="Hong S" first="Se Hyang" last="Hong">Se Hyang Hong</name>
<affiliation><nlm:aff id="af2-nutrients-12-00196">Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>sehyang@khu.ac.kr</email>
 (S.H.H.);<email>saory_ykm@naver.com</email>
 (J.M.K.)</nlm:aff>
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</author>
<author><name sortKey="Ku, Jin Mo" sort="Ku, Jin Mo" uniqKey="Ku J" first="Jin Mo" last="Ku">Jin Mo Ku</name>
<affiliation><nlm:aff id="af2-nutrients-12-00196">Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>sehyang@khu.ac.kr</email>
 (S.H.H.);<email>saory_ykm@naver.com</email>
 (J.M.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Min Jeong" sort="Kim, Min Jeong" uniqKey="Kim M" first="Min Jeong" last="Kim">Min Jeong Kim</name>
<affiliation><nlm:aff id="af1-nutrients-12-00196">Department of Science in Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>hi9265@nate.com</email>
 (H.I.K.);<email>jung8328@hanmail.net</email>
 (M.J.K.);<email>seonca@naver.com</email>
 (S.W.J.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ju, Sung Wan" sort="Ju, Sung Wan" uniqKey="Ju S" first="Sung Wan" last="Ju">Sung Wan Ju</name>
<affiliation><nlm:aff id="af1-nutrients-12-00196">Department of Science in Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>hi9265@nate.com</email>
 (H.I.K.);<email>jung8328@hanmail.net</email>
 (M.J.K.);<email>seonca@naver.com</email>
 (S.W.J.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang, Seok Won" sort="Chang, Seok Won" uniqKey="Chang S" first="Seok Won" last="Chang">Seok Won Chang</name>
<affiliation><nlm:aff id="af3-nutrients-12-00196">Department of Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>jsw2333@hanmail.net</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cheon, Chunhoo" sort="Cheon, Chunhoo" uniqKey="Cheon C" first="Chunhoo" last="Cheon">Chunhoo Cheon</name>
<affiliation><nlm:aff id="af2-nutrients-12-00196">Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>sehyang@khu.ac.kr</email>
 (S.H.H.);<email>saory_ykm@naver.com</email>
 (J.M.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ko, Seong Gyu" sort="Ko, Seong Gyu" uniqKey="Ko S" first="Seong-Gyu" last="Ko">Seong-Gyu Ko</name>
<affiliation><nlm:aff id="af2-nutrients-12-00196">Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea;<email>sehyang@khu.ac.kr</email>
 (S.H.H.);<email>saory_ykm@naver.com</email>
 (J.M.K.)</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Gliomas are the most observed primary brain tumor, of which glioblastoma multiform (GBM) shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic method, but because of side effects, search for alternative therapies is required. <italic>Gardenia jasminoides</italic>
 (GJ) is flavonoid abundant with beneficial effects on inflammation, metabolic diseases, and cancers. In this study, we investigated the synergistic combination of GJ and cisplatin (CDDP) in U87MG and U373MG GBM cells. GJ and CDDP both showed cytotoxicity in U87MG cells, however GJ did not affect viability of normal astrocytes while CDDP displayed high toxicity. Cytotoxic effect of GJ and CDDP was related in apoptosis when confirmed by Western blot assays on cleaved caspase-3, caspase-9, and PARP. Moreover, GJ and CDDP showed synergistic combination in cell death of GBM cells, which was further confirmed by Western blot assays of apoptosis factors and also flow cytometry of Annexin V. Analysis on autophagy factors showed that GJ/CDDP combination induced autophagy, and through inhibition of autophagy, we could confirm autophagy is crucial to cytotoxicity of GJ/CDDP in GBM cell lines. The autophagy-mediated apoptosis of GJ/CDDP was dependent on the AKT/mTOR pathway. Overall, our results suggest GJ/CDDP combination as an effective yet safe therapeutic approach to GBMs.</p>
</div>
</front>
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<name sortKey="Cheon, Chunhoo" sort="Cheon, Chunhoo" uniqKey="Cheon C" first="Chunhoo" last="Cheon">Chunhoo Cheon</name>
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   |texte=   Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes
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Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

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